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Aseptic meningitis associated with chronic sulindac use for osteoarthritis: a case report.

Abstract
We report a case of aseptic meningitis thought to be associated with chronic sulindac use in a patient with osteoarthritis. The patient was hospitalized with an acute onset of headache, nuchal rigidity, nausea, and blurred vision. Brain imaging was unremarkable and a lumbar puncture revealed a lymphocytic pleocytosis. No infectious source was identified. The patient reported taking sulindac over the past year, it was discontinued, and symptoms promptly resolved. This case underscores the importance of obtaining a thorough drug history in conjunction with the knowledge of causative medications associated with aseptic meningitis. Given the widespread use of nonsteroidal anti-inflammatory drugs, clinicians must recognize that aseptic meningitis is a possible adverse effect of these medications.
AuthorsErin C Callen, Chelsea O Church, Manish Patel, Tiffany L Sikes
JournalRheumatology international (Rheumatol Int) Vol. 28 Issue 4 Pg. 391-3 (Feb 2008) ISSN: 0172-8172 [Print] Germany
PMID17703306 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Sulindac
Topics
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
  • Humans
  • Male
  • Meningitis, Aseptic (chemically induced)
  • Osteoarthritis (drug therapy)
  • Risk Factors
  • Sulindac (adverse effects)

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