| Abstract | OBJECTIVE: The aim of the present study was to compare the effects of raloxifene and low-dose hormone replacement therapy (HRT) on bone mineral density (BMD) and bone turnover markers in the treatment of postmenopausal osteoporosis. METHODS: Forty-two postmenopausal osteoporotic women, who were randomized to receive raloxifene 60 mg or estradiol 1 mg/norethisterone acetate 0.5 mg daily for 1 year, were studied. All women received calcium 600 mg/day and vitamin D 400 IU/day. BMD and markers of bone turnover were measured at baseline and at 12 months. RESULTS: After 12 months of treatment, there were statistically significant increases in BMD in both groups at all sites (all p < 0.05). For the lumbar spine, the increase in BMD was 2.3% for raloxifene compared with 5.8% for low-dose HRT and corresponding values for total body BMD were 2.9% for raloxifene and 4.6% for low-dose HRT; the increases being significantly greater in the low-dose HRT group (p < 0.001 and p = 0.02, respectively). Although the increase in BMD at the hip was significant for both raloxifene (2.1%) and low-dose HRT (3.2%) compared with baseline, the difference between the two regimens did not reach statistical significance. The decrease in serum C-terminal telopeptide fragment of type I collagen and serum osteocalcin levels for the low-dose HRT group (-53% and -47%, respectively) was significantly greater than for the raloxifene group (-23% and -27%, respectively; both p < 0.01). CONCLUSIONS: In postmenopausal women with osteoporosis, low-dose HRT produced significantly greater increases in BMD of the lumbar spine and total body and greater decreases in bone turnover than raloxifene at 12 months. |
| Authors | Cem Dane, Banu Dane, Ahmet Cetin, Murat Erginbas
(Affiliation: Haseki Training & Research Hospital, Department of Gynecology & Obstetrics, Istanbul, Turkey. cemdane at yahoo.com)
|
| Journal | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
(Gynecol Endocrinol)
Vol. 23
Issue 7
Pg. 398-403
(Jul 2007)
ISSN: 0951-3590 England |
| PMID | 17701771
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
|
| Chemical References |
- Bone Density Conservation Agents
- Collagen Type I
- Drug Combinations
- Peptides
- collagen type I trimeric cross-linked peptide
- Osteocalcin
- Estradiol
- Norethindrone
- Raloxifene
|
| Topics |
- Bone Density
(drug effects)
- Bone Density Conservation Agents
(pharmacology)
- Collagen Type I
(blood, drug effects)
- Drug Combinations
- Estradiol
(pharmacology)
- Estrogen Replacement Therapy
- Female
- Humans
- Norethindrone
(pharmacology)
- Osteocalcin
(blood, drug effects)
- Osteoporosis
(drug therapy)
- Peptides
(blood, drug effects)
- Postmenopause
- Raloxifene
(pharmacology)
|
