Abstract | BACKGROUND: One week of Helicobacter pylori eradication therapy is insufficient for healing of gastric ulcers. We examined the efficacy of rebamipide in gastric ulcer healing following 1 week of eradication therapy in a randomized, double-blind, placebo-controlled trial. METHODS: Patients with H. pylori-positive gastric ulcer were enrolled and received 1 week of eradication therapy, followed by 100 mg of rebamipide or placebo for 7 weeks. The primary end point was the gastric ulcer healing rate. RESULTS: Of the 309 patients entered in the trial, 301 completed H. pylori eradication therapy; 154 patients took rebamipide, and 147 took placebo. The healing rate in the rebamipide group was higher than that in the placebo group in the per-protocol analysis-80.0% (104/130) versus 66.1% (82/124) [95% confidence interval (CI), 3.1-24.7; P = 0.013)-and in a full analysis-70.1% (108/154) versus 60.5% (89/147) (95% CI, -1.1 to 20.3; P = 0.080). CONCLUSIONS:
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Authors | Akira Terano, Tetsuo Arakawa, Toshiro Sugiyama, Hidekazu Suzuki, Takashi Joh, Toshikazu Yoshikawa, Kazuhide Higuchi, Ken Haruma, Kazunari Murakami, Kenzo Kobayashi, Rebamipide Clinical Study Group |
Journal | Journal of gastroenterology
(J Gastroenterol)
Vol. 42
Issue 8
Pg. 690-3
(Aug 2007)
ISSN: 0944-1174 [Print] Japan |
PMID | 17701133
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Enzyme Inhibitors
- Proton Pump Inhibitors
- Quinolones
- Lansoprazole
- Amoxicillin
- Clarithromycin
- rebamipide
- Alanine
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
(therapeutic use)
- Adult
- Alanine
(analogs & derivatives, therapeutic use)
- Amoxicillin
(therapeutic use)
- Anti-Bacterial Agents
(therapeutic use)
- Anti-Ulcer Agents
(therapeutic use)
- Clarithromycin
(therapeutic use)
- Double-Blind Method
- Endoscopy, Gastrointestinal
- Enzyme Inhibitors
(therapeutic use)
- Female
- Follow-Up Studies
- Gastric Mucosa
(microbiology, pathology)
- Helicobacter Infections
(drug therapy, epidemiology, pathology)
- Helicobacter pylori
(isolation & purification)
- Humans
- Japan
(epidemiology)
- Lansoprazole
- Male
- Middle Aged
- Prevalence
- Proton Pump Inhibitors
- Quinolones
(therapeutic use)
- Retrospective Studies
- Stomach Ulcer
(drug therapy, epidemiology, pathology)
- Treatment Outcome
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