HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats.

Abstract
Amylin infusion reduces food intake and slows body weight gain in rodents. In obese male rats, amylin (but not pair feeding) caused a preferential reduction of fat mass with protein preservation despite equal body weight loss in amylin-treated (fed ad libitum) and pair-fed rats. In the present study, the effect of prior or concurrent food restriction on the ability of amylin to cause weight loss was evaluated. Retired female breeder rats were maintained on a high-fat diet (40% fat) for 9 wk. Prior to drug treatment, rats were either fed ad libitum or food restricted for 10 days to lose 5% of their starting body weight. They were then subdivided into treatment groups that received either vehicle or amylin (100 microgxkg(-1)xday(-1) via subcutaneous minipump) and placed under either a restricted or ad libitum feeding schedule (for a total of 8 treatment arms). Amylin 1) significantly reduced body weight compared with vehicle under all treatment conditions, except in always restricted animals, 2) significantly decreased percent body fat in all groups, and 3) preserved lean mass in all groups. These results indicate that amylin's anorexigenic and fat-specific weight loss properties can be extended to a variety of nutritive states in female rats.
AuthorsJonathan D Roth, Heather Hughes, Todd Coffey, Holly Maier, James L Trevaskis, Christen M Anderson
JournalAmerican journal of physiology. Endocrinology and metabolism (Am J Physiol Endocrinol Metab) Vol. 293 Issue 4 Pg. E1112-7 (Oct 2007) ISSN: 0193-1849 [Print] United States
PMID17698985 (Publication Type: Comparative Study, Evaluation Study, Journal Article)
Chemical References
  • Amyloid
  • Dietary Fats
  • Islet Amyloid Polypeptide
  • Leptin
Topics
  • Algorithms
  • Amyloid (blood, pharmacology)
  • Animals
  • Body Composition (drug effects)
  • Body Weight (drug effects)
  • Caloric Restriction
  • Diet, Atherogenic
  • Dietary Fats (pharmacology)
  • Eating (drug effects)
  • Female
  • Gene Expression Profiling
  • Islet Amyloid Polypeptide
  • Leptin (blood)
  • Liver (metabolism)
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: