Frequency of the G/G genotype of resistin single nucleotide polymorphism at -420 appears to be increased in younger-onset type 2 diabetes.

Abstract

OBJECTIVE:

Resistin is an adipocyte-secreted cytokine associated with insulin resistance in mice. We previously reported that the G/G genotype of a resistin single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes susceptibility by enhancing its promoter activity. The aim of the present study was to determine the relevance of SNP -120 in a large number of subjects.

RESEARCH DESIGN AND METHODS:

We examined 2,610 type 2 diabetic case and 2,502 control subjects. The relation between SNP -420 and the age of type 2 diabetes onset was further analyzed by adding 237 type 2 diabetic subjects with age of onset <or=40 years.

RESULTS:

When analyzed without considering subject age, the SNP -420 genotype was not associated with type 2 diabetes. Since we reported that the onset of type 2 diabetes was earlier in G/G genotype, we analyzed the data using a trend test for age intervals of 10 years. The frequency of G/G genotype differed among age grades in type 2 diabetes (P = 0.037) and appeared to be higher in younger grades. In type 2 diabetes, G/G genotype was more frequent in subjects aged <40 years than in those aged >or=40 years (G/G vs. C/C, P = 0.003). In a total of 2,430 type 2 diabetic subjects with age of onset <60 years, the trend test showed that the G/G genotype had an increasing linear trend as the age grade of type 2 diabetes onset became younger (P = 0.0379). In control subjects, the frequency of C/G genotype showed an increasing linear trend with increasing age (P = 0.010).

CONCLUSIONS:

The G/G genotype frequency of resistin SNP -420 appears to be increased in younger-onset type 2 diabetic subjects.

• Authors: Masaaki Ochi, Haruhiko Osawa, Yushi Hirota, Kazuo Hara, Yasuharu Tabara, Yoshiharu Tokuyama, Ikki Shimizu, Azuma Kanatsuka, Yasuhisa Fujii, Jun Ohashi, Tetsuro Miki, Naoto Nakamura, Takashi Kadowaki, Mitsuo Itakura, Masato Kasuga, Hideichi Makino
• Journal: Diabetes (Diabetes) Vol. 56 Issue 11 Pg. 2834-8 (Nov 2007) ISSN: 1939-327X [Electronic] United States
• PMID: 17698599 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Resistin
• Guanine

Topics

• Adult
• Age of Onset
• Animals
• Diabetes Mellitus, Type 2 (genetics)
• Gene Frequency
• Genotype
• Guanine
• Humans
• Mice
• Mice, Knockout
• Middle Aged
• Polymorphism, Single Nucleotide
• Reference Values
• Resistin (deficiency, genetics)