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Roles of neuropeptides in O,O,S-trimethylphosphorothioate (OOS-TMP)-induced anorexia in mice.

Abstract
O,O,S-Trimethylphosphorothioate (OOS-TMP), an impurity present in various organophosphorus insecticides, has previously been shown to induce hypophagia. The major goal of this study was to investigate its mechanism of action. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injection transiently induced hypophagia at a dose of 5mg/kg within 6h, without causing lung injury. Hypophagia was accompanied by up-regulation of corticotropin releasing factor (CRF) (2.92+/-0.45 vs. 1.7+/-0.5, at 2h after i.c.v., 3.40+/-1.38 vs. 1.76+/-0.41 at 6h after i.p., P<0.05) in the hypothalamus. After i.c.v. injection, hypophagia recovered by 6h after dosing. At doses higher than 5mg/kg, i.c.v. injection induced continuous hypophagia from 20min to 72h after dosing, accompanied by hypothermia and lung injury. OOS-TMP was considered to induce hypophagia through enhancing expression of CRF.
AuthorsLinfang Huang, Megumi Toyoshima, Akihiro Asakawa, Kayoko Inoue, Kouji Harada, Tomomi Kinoshita, Akio Koizumi
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 362 Issue 1 Pg. 177-182 (Oct 12 2007) ISSN: 0006-291X [Print] United States
PMID17698039 (Publication Type: Journal Article)
Chemical References
  • Esters
  • Neuropeptides
  • Organothiophosphates
  • RNA, Messenger
  • O,O,S-trimethyl phosphorothioate
  • Corticotropin-Releasing Hormone
Topics
  • Animals
  • Anorexia (metabolism)
  • Body Temperature
  • Corticotropin-Releasing Hormone (metabolism)
  • Esters (chemistry)
  • Feeding Behavior
  • Hypothalamus (metabolism, pathology)
  • Lung Injury
  • Male
  • Mice
  • Neuropeptides (chemistry)
  • Organothiophosphates (chemistry, metabolism)
  • RNA, Messenger (metabolism)
  • Temperature
  • Time Factors

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