Abstract |
Nanoliposomes are useful carriers in drug delivery. Radiolabeled nanoliposomes have potential applications in radiotherapy and diagnostic imaging. In this study, the biodistribution and pharmacokinetics of 188Re-BMEDA-labelled pegylated liposomes (RBLPL) and unencapsulated 188Re-BMEDA administered by the i.v. route in murine C26-colon tumour-bearing mice were investigated. MicroSPECT/CT images were performed to evaluate the distribution and tumor targeting of RBLPL in mice. For the biodistribution study, the highest uptake of liposome in tumors was 3.62% +/- 0.73% at 24 h after RBLPL administration, and the tumor to muscle ratio of RBLPL was 7.1-fold higher than that of 188Re-BMEDA. With image analysis, the highest SUV in tumor was 2.81 +/- 0.26 at 24 h after injection of RBLPL. The Pearson correlation analysis showed a positive correlation of tumor targeting or uptake of RBLPL between biodistribution and microSPECT semi-quantification imaging analysis (r = 0.633). The results of the pharmacokinetics revealed that the area under the tissue concentration-time curve (AUC) of RBLPL was 4.7-fold higher than that of unencapsulated 188Re-BMEDA. These results suggested the potential benefit and advantage of 188Re-labeled nanoliposomes for imaging and treatment of malignant diseases.
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Authors | Ya-Jen Chang, Chih-Hsien Chang, Tsui-Jung Chang, Chia-Yu Yu, Liang-Cheng Chen, Meei-Lin Jan, Tsai-Yueh Luo, Te-Wei Lee, Gann Ting |
Journal | Anticancer research
(Anticancer Res)
2007 Jul-Aug
Vol. 27
Issue 4B
Pg. 2217-25
ISSN: 0250-7005 [Print] Greece |
PMID | 17695506
(Publication Type: Journal Article)
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Chemical References |
- 188Re-N,N-bis(2-mercaptoethyl)-N',N'-diethylethylenediamine
- Ethylenediamines
- Liposomes
- Organometallic Compounds
- Radioisotopes
- Radiopharmaceuticals
- Rhenium
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Topics |
- Animals
- Cell Line, Tumor
- Colonic Neoplasms
(diagnostic imaging, metabolism)
- Disease Models, Animal
- Drug Stability
- Ethylenediamines
(administration & dosage, chemistry, pharmacokinetics)
- Isotope Labeling
- Liposomes
- Male
- Mice
- Mice, Inbred BALB C
- Organometallic Compounds
(administration & dosage, chemistry, pharmacokinetics)
- Radioisotopes
- Radiopharmaceuticals
(administration & dosage, chemistry, pharmacokinetics)
- Rhenium
(chemistry)
- Tissue Distribution
- Tomography, Emission-Computed, Single-Photon
- Tomography, X-Ray Computed
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