Persistence of systemic mastocytosis after allogeneic bone marrow transplantation in spite of complete remission of the associated myelodysplastic syndrome.

Abstract

A myelodysplastic syndrome (MDS), type 5 (RAEB-t), and systemic mastocytosis affecting the spleen, the splenic lymph nodes, the bone marrow and the liver were diagnosed in a 38-year-old woman. The clinical course was complicated by splenic vein thromboses and iliac artery embolism. The thrombotic episodes might be secondary to mast cell mediator release. A complete remission of the MDS was obtained by allogeneic bone marrow transplantation, but the mastocytosis persisted. Thus, the possibility that the mast cell originates from a common myeloid precursor cell may be questioned.

• Authors: D Rønnov-Jessen, P Løvgreen Nielsen, T Horn
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 8 Issue 5 Pg. 413-5 (Nov 1991) ISSN: 0268-3369 [Print] England
• PMID: 1768977 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Bone Marrow Transplantation
• Embolism (complications)
• Female
• Hematopoietic Stem Cells (pathology)
• Humans
• Iliac Artery
• Mast Cells (pathology)
• Mastocytosis (complications, pathology, surgery)
• Myelodysplastic Syndromes (complications, pathology, surgery)
• Splenic Vein
• Thrombophlebitis (complications)