[Neuroendocrine carcinoma of the prostate effectively treated by cisplatin and irinotecan--a case report].

Abstract

A 79-year-old man was referred to our hospital with urinary retention in August 2004. Because the serum PSA was 2,9 39 ng/mL,we performed transabdominal prostatic needle biopsy. Pathological examination of the prostate revealed conventional adenocarcinoma. CT scans and MRI showed a huge mass and lymph node metastasis. He was treated with diethyl stilbestrol diphosphate,followed by maximal androgen blockade therapy,and the serum PSA level decreased favorably. Follow-up CT revealed prostate and lymph node metastasis were reduced, but liver metastases, measuring 45 x 34 mm and 28 x 24 mm, respectively, were newly recognized in February 2006. The NSE level was high at 88.5 ng/mL, so a percutaneous liver biopsy was performed,and pathological examination of the liver revealed metastatic prostate cancer which showed neuroendocrine differentiation. The treatment was changed to chemotherapy comprising cisplatin and irinotecan. After three courses of the chemotherapy,liver metastasis was reduced in CT scans.

• Authors: Shogo Inoue, Kiyotaka Oka, Teruo Araki, Akira Yano, Takatoshi Tacho, Motohiro Fujii, Kuniharu Kimoto, Michiyasu Murakami, Yumi Ohshiro
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 8 Pg. 1323-5 (Aug 2007) ISSN: 0385-0684 [Print] Japan
• PMID: 17687224 (Publication Type: Case Reports, Journal Article)

Chemical References

• Irinotecan
• Prostate-Specific Antigen
• Cisplatin
• Camptothecin

Topics

• Adenocarcinoma (drug therapy, secondary)
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives)
• Carcinoma, Neuroendocrine (pathology)
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Humans
• Irinotecan
• Liver Neoplasms (pathology, secondary)
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Male
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms (drug therapy, pathology)