Objective To study the protective effect and mechanism of
Shuxuetong on gerbil brain tissue from the area of
ischemia-reperfusion. Methods
Cerebral ischemia-reperfusion animal model has made by transient clipping bilateral common carotid arteries in gerbils. Pathological changes in the hippocampal tissue were observed at different reperfusion time (12h, 3 d, 7 d). The expression levels of
GABA and
TNF-alpha in the hippocampal CA1 subfield were observed using immunohistochemitry at 12 h, 3 d after reperfusion. The difference of above indices among false operation group,
ischemia-reperfusion group and treatment group were compared. Results The
injuries of pathology to hippocampal area in
ischemia reperfusion group were more serious than treatment group. The expression levels of
GABA in treatment group were significantly increased compared with
ischemia-reperfusion group, but the expression levels of
TNF-alpha between the two groups have no difference. Conclusion
Shuxuetong has protective effect on brain tissue of
ischemia-reperfusion by enhancing the expression of
GABA in the hippocampal tissue.