HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents.

Abstract
A series of cinnamyl compounds related to 2'-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G(2)/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.
AuthorsDae-Seop Shin, Jiin Kim, Dong Cho Han, Kwang-Hee Son, Chang Woo Lee, Hwan-Mook Kim, Su Hyung Hong, Byoung-Mog Kwon
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 17 Issue 19 Pg. 5423-7 (Oct 01 2007) ISSN: 0960-894X [Print] England
PMID17683933 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Cinnamates
  • Enzyme Inhibitors
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Caspase 3
Topics
  • Animals
  • Antineoplastic Agents (chemical synthesis, pharmacology)
  • Apoptosis (drug effects)
  • Caspase 3 (biosynthesis)
  • Cell Cycle (drug effects)
  • Cell Division (drug effects)
  • Cell Line, Tumor
  • Cinnamates (chemical synthesis, pharmacology)
  • Cinnamomum (chemistry)
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors (chemical synthesis, pharmacology)
  • G2 Phase (drug effects)
  • Humans
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Poly(ADP-ribose) Polymerase Inhibitors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: