Abstract |
A series of cinnamyl compounds related to 2'-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G(2)/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.
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Authors | Dae-Seop Shin, Jiin Kim, Dong Cho Han, Kwang-Hee Son, Chang Woo Lee, Hwan-Mook Kim, Su Hyung Hong, Byoung-Mog Kwon |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 17
Issue 19
Pg. 5423-7
(Oct 01 2007)
ISSN: 0960-894X [Print] England |
PMID | 17683933
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Cinnamates
- Enzyme Inhibitors
- Poly(ADP-ribose) Polymerase Inhibitors
- Caspase 3
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Topics |
- Animals
- Antineoplastic Agents
(chemical synthesis, pharmacology)
- Apoptosis
(drug effects)
- Caspase 3
(biosynthesis)
- Cell Cycle
(drug effects)
- Cell Division
(drug effects)
- Cell Line, Tumor
- Cinnamates
(chemical synthesis, pharmacology)
- Cinnamomum
(chemistry)
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
(chemical synthesis, pharmacology)
- G2 Phase
(drug effects)
- Humans
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Poly(ADP-ribose) Polymerase Inhibitors
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