Effects of L-histidinol on the proliferation and anticancer drug susceptibility of cultured B16f10 melanoma cells.

Abstract

L-Histidinol, a structural analogue of the essential amino acid L-histidine, is able to enhance the toxicity of a wide variety of anticancer drugs to tumor cells both in vitro and in vivo. In this study, the effects of L-histidinol on the viability, cell cycle traverse and anticancer drug susceptibility of B16f10 melanoma cells in culture have been examined. L-Histidinol inhibited the transit of B16f10 melanoma cells through the cell cycle in a dose-dependent manner. In spite of its capacity to slow cell cycle progression, L-histidinol nevertheless increased the capacity of several antineoplastic agents of varying modes of action to kill B16f10 melanoma cells.

• Authors: R C Warrington, I Cheng, W Fang
• Journal: Anticancer research (Anticancer Res) 1991 Sep-Oct Vol. 11 Issue 5 Pg. 1863-7 ISSN: 0250-7005 [Print] Greece
• PMID: 1768057 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytarabine
• Histidinol
• Vinblastine
• Fluorouracil
• Carmustine

Topics

• Carmustine (pharmacology)
• Cell Division (drug effects)
• Cytarabine (pharmacology)
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• Fluorouracil (pharmacology)
• Histidinol (pharmacology)
• Interphase (drug effects)
• Melanoma, Experimental (drug therapy, pathology)
• Time Factors
• Vinblastine (pharmacology)