Abstract | OBJECTIVE: METHODS: One hundred eumenorrhea women were chosen as control group and another 100 hypomenorrhea patients as case group from Southwestern China. Restriction fragment length polymorphism (RFLP) of the Rsa I and Alu I in ER beta gene was analysed. The ER beta gene polymorphism genotype distribution in case group and control group was compared. RESULTS: R allele frequency in case and control groups was 37.5% and 48.5% respectively, the OR was 0.64 (95%CI: 0.42-0.97), P= 0.026. A allele frequency in case and control groups was 18.0% and 11.5% respectively, the OR was 1.69 (95%CI: 0.93-3.09), P= 0.07. RFLP of Rsa I and Alu I in both groups were distributed with polymorphism. CONCLUSION:
ERbeta gene polymorphism has a relation with unknown aetiological hypomenorrhea. R allele may be the guard factor, and A allele may be its risk factor.
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Authors | Rui Yuan, Ai-wen Le, Li Gen, En-lan Xia, Zhen-wei Yao |
Journal | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
(Zhonghua Yi Xue Yi Chuan Xue Za Zhi)
Vol. 24
Issue 4
Pg. 425-7
(Aug 2007)
ISSN: 1003-9406 [Print] China |
PMID | 17680534
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Estrogen Receptor beta
- endodeoxyribonuclease AluI
- Deoxyribonucleases, Type II Site-Specific
- GTAC-specific type II deoxyribonucleases
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Topics |
- Adult
- Binding Sites
(genetics)
- Deoxyribonucleases, Type II Site-Specific
(metabolism)
- Estrogen Receptor beta
(genetics)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
(genetics)
- Genotype
- Humans
- Menstruation Disturbances
(etiology, genetics)
- Polymerase Chain Reaction
- Polymorphism, Genetic
(genetics)
- Polymorphism, Restriction Fragment Length
- Young Adult
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