| Abstract | Acute pancreatitis (AP) is the severe disease with high mortality and morbidity which pathomechanism is still not clearly elucidated yet. Serum pro-inflammatory cytokines like Interleukin-18, TNF alpha, and C-reactive protein (CRP) are elevated in patients with AP, particularly of severe clinical course. Adipocytes hyperplasia is a trigger factor that initiates chronic inflammatory state which release adipocytokines, like TNF alpha or leptin or resistin. The aim of the present study was to assesses the serum resistin concentrations in AP patients and evaluate the correlation between resistin and the well known inflammation marker--CRP. MATERIAL AND METHODS: The study group comprised 30 patients with acute pancreatitis class B according to Balthazar scale, aged 35-82, in which during first 24h of hospitalization serum resistin and CRP has been assessed. Control group consisted of 30 healthy volunteers, aged 33-76. RESULTS: The mean serum resistin concentration was significantly higher in AP patients than in controls (8,38 +/- 4.87 ng/ml vs. 3.58 +/- 1.51 ng/ml) (fig. 1). The positive correlation between serum resistin and CRP concentrations has been observed (r = 0.57, p < 0.05) (fig. 2). CONCLUSIONS: The results of our study suggest, that the serum concentration of resistin may represent the useful additionary marker of inflammatory response in AP |
| Authors | Bartosz Leśniowski, Anna Kumor, Anna Jasińska, Piotr Daniel, Mirosława Pietruczuk, Ewa Małecka-Panas
(Affiliation: Klinika Chorób Przewodu Pokarmowego Uniwersytetu Medycznego w Łodzi.)
|
| Journal | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
(Pol Merkur Lekarski)
Vol. 22
Issue 131
Pg. 385-7
(May 2007)
ISSN: 1426-9686 Poland |
| Vernacular Title | Rezystyna--nowy marker laboratoryjny przydatny w rozpoznaniu ostrego zapalenia trzustki? |
| PMID | 17679375
(Publication Type: English Abstract, Evaluation Studies, Journal Article)
|
| Chemical References |
- Adiponectin
- Biological Markers
- Resistin
- C-Reactive Protein
|
| Topics |
- Acute Disease
- Adiponectin
(blood)
- Adult
- Aged
- Aged, 80 and over
- Analysis of Variance
- Biological Markers
(blood)
- C-Reactive Protein
(analysis)
- Feasibility Studies
- Female
- Humans
- Male
- Middle Aged
- Pancreatitis
(blood, diagnosis, pathology)
- Predictive Value of Tests
- Prognosis
- Reference Values
- Resistin
(blood)
- Sensitivity and Specificity
- Severity of Illness Index
- Statistics, Nonparametric
|
