| Abstract | The efficacy of the inhibitors of acetylcholinesterase in Alzheimer's Disease (AD) is moderated and some patients do not respond to these treatments. Sulbutiamine potentializes cholinergic and glutamatergic transmissions, mainly in hippocampus and prefrontal cortex. This multicentric, randomized and double-blind trial evaluates the effects of the association of sulbutiamine to an anticholinesterasic drug in cognitive functions in patients with AD at an early stage (episodic memory, working memory, executive functions, attention). Patients had first donepezil (D) or sulbutiamine (S) during three months. During this period, only attention improved in both groups. During the three following months, a placebo (P) in patients D and donepezil in patients S were added. Compared to entry results, episodic memory decreased in group D + P but improved in group S + D. At the same time the improvement of attention persisted in both groups. Daylife activities only improved in group S + D. In conclusion sulbutiamine can be an adjuvant to treatment in early stage and moderate AD by anticholinesterasic drugs. |
| Authors | H Ollat, B Laurent, S Bakchine, B-F Michel, J Touchon, B Dubois
(Affiliation: Association pour la Neuro Psycho Pharmacologie, 25 rue de la Plaine, 75020 Paris.)
|
| Journal | L'Encéphale
(Encephale)
2007 Mar-Apr
Vol. 33
Issue 2
Pg. 211-5
ISSN: 0013-7006 France |
| Vernacular Title | Effets de l'association de la Sulbutiamine à un inhibiteur de l'acétylcholinestérase dans les formes légères à modérées de la maladie d'Alzheimer. |
| PMID | 17675917
(Publication Type: English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
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| Chemical References |
- Cholinesterase Inhibitors
- Indans
- Piperidines
- donepezil
- sulbutiamine
- Thiamine
|
| Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(drug therapy)
- Attention
(drug effects)
- Brain
(drug effects)
- Cholinesterase Inhibitors
(pharmacology, therapeutic use)
- Drug Therapy, Combination
- Female
- Hippocampus
(drug effects)
- Humans
- Indans
(pharmacology, therapeutic use)
- Male
- Middle Aged
- Piperidines
(pharmacology, therapeutic use)
- Prefrontal Cortex
(drug effects)
- Severity of Illness Index
- Thiamine
(analogs & derivatives, pharmacology, therapeutic use)
|
