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Type I lepra reaction presenting as immune reconstitution inflammatory syndrome.

Abstract
Immune reconstitution inflammatory syndrome (IRIS) is an unusual inflammatory reaction due to infectious and non-infectious causes occurring in human Immunodeficiency virus (HIV)-infected patients. IRIS occurs after the initiation of antiretroviral therapy. There are no reports of type I lepra reaction due to IRIS in published literature from India. We report two cases of HIV-infected males who presented with borderline tuberculoid leprosy in type 1 reaction after the initiation of highly active antiretroviral treatment (HAART). Case 1 presented with multiple, tender, erythematous and hypoesthetic plaques on the trunk and extremities after 3 months of antiretroviral therapy. In case 2, type I lepra reaction was observed 2 months after the initiation of HAART.
AuthorsVidya Kharkar, Urmila H Bhor, Sunanda Mahajan, Uday Khopkar
JournalIndian journal of dermatology, venereology and leprology (Indian J Dermatol Venereol Leprol) 2007 Jul-Aug Vol. 73 Issue 4 Pg. 253-6 ISSN: 0973-3922 [Electronic] United States
PMID17675735 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Leprostatic Agents
Topics
  • AIDS-Related Opportunistic Infections (chemically induced)
  • Adult
  • Antiretroviral Therapy, Highly Active (adverse effects)
  • CD4 Lymphocyte Count
  • HIV Infections (complications, immunology)
  • Humans
  • Hypersensitivity (diagnosis, etiology)
  • Leprostatic Agents (therapeutic use)
  • Leprosy, Borderline (chemically induced, diagnosis)
  • Leprosy, Tuberculoid (chemically induced, diagnosis)
  • Male
  • Skin (pathology)
  • Syndrome

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