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Transcriptomic analysis of the sulfate starvation response of Pseudomonas aeruginosa.

Abstract
Pseudomonas aeruginosa is an opportunistic pathogen that causes a number of infections in humans, but is best known for its association with cystic fibrosis. It is able to use a wide range of sulfur compounds as sources of sulfur for growth. Gene expression in response to changes in sulfur supply was studied in P. aeruginosa E601, a cystic fibrosis isolate that displays mucin sulfatase activity, and in P. aeruginosa PAO1. A large family of genes was found to be upregulated by sulfate limitation in both isolates, encoding sulfatases and sulfonatases, transport systems, oxidative stress proteins, and a sulfate-regulated TonB/ExbBD complex. These genes were localized in five distinct islands on the genome and encoded proteins with a significantly reduced content of cysteine and methionine. Growth of P. aeruginosa E601 with mucin as the sulfur source led not only to a sulfate starvation response but also to induction of genes involved with type III secretion systems.
AuthorsTewes Tralau, Stéphane Vuilleumier, Christelle Thibault, Barry J Campbell, C Anthony Hart, Michael A Kertesz
JournalJournal of bacteriology (J Bacteriol) Vol. 189 Issue 19 Pg. 6743-50 (Oct 2007) ISSN: 0021-9193 [Print] United States
PMID17675390 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Mucins
  • Sulfates
Topics
  • Gene Expression Profiling
  • Gene Expression Regulation, Bacterial (drug effects)
  • Genome, Bacterial
  • Mucins (pharmacology)
  • Oligonucleotide Array Sequence Analysis
  • Pseudomonas aeruginosa (genetics)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sulfates (pharmacology)
  • Transcription, Genetic (drug effects)

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