Effects of 7-hydroxy-3-methoxycadalene on cell cycle, apoptosis and protein translation in A549 lung cancer cells.

Abstract

Previously we reported that cadalene extracted from Zelkova serrata inhibited lung tumorigenesis in mice. However, the precise mechanism has not yet investigated. Here, we examined the effects of cadalene on signal pathways important for apoptosis, cell cycle, and protein translation in lung cancer cells. Our results showed that cadalene suppressed the expression of Akt and its phosphor-forms through controlling PI3K and PTEN. Cadalene also induced apoptosis through facilitating pro-apoptotic protein expression. In addition, cadalene caused cell cycle arrest and decreased mTOR-mediated protein translation. Taken together, cadalene may be developed as a lung cancer therapeutic agent in the future.

• Authors: Hua Jin, Hyun-Woo Kim, Cheng-Xiong Xu, Jung-Taek Kwon, Soon-Kyung Hwang, Eun-Sun Lee, Seung-Hee Chang, Sung-Jin Park, Mi-Suk Noh, Min-Ah Woo, Kyeong-Nam Yu, Hu-Jang Lee, Joon-Weon Choi, Don-Ha Choi, Myung-Haing Cho
• Journal: BioFactors (Oxford, England) (Biofactors) Vol. 29 Issue 2-3 Pg. 67-75 ( 2007) ISSN: 0951-6433 [Print] Netherlands
• PMID: 17673824 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 7-hydroxy-3-methoxy-cadalene
• Antineoplastic Agents, Phytogenic
• Polycyclic Sesquiterpenes
• Sesquiterpenes
• Proto-Oncogene Proteins c-akt
• PTEN Phosphohydrolase
• PTEN protein, human

Topics

• Antineoplastic Agents, Phytogenic (pharmacology)
• Apoptosis (drug effects)
• Cell Cycle (drug effects)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Humans
• Lung Neoplasms (pathology)
• PTEN Phosphohydrolase (metabolism)
• Phosphatidylinositol 3-Kinases (metabolism)
• Polycyclic Sesquiterpenes
• Protein Biosynthesis (drug effects)
• Proto-Oncogene Proteins c-akt (biosynthesis)
• Sesquiterpenes (pharmacology)
• Signal Transduction (drug effects)