Phenoxymethylpenicillin two or three times daily for tonsillitis with beta-haemolytic streptococci group A: a blinded, randomized and controlled clinical study.

In relation to compliance problems it was investigated whether phenoxymethylpenicillin dosed twice or 3 times daily was equally effective in tonsillitis due to beta-haemolytic streptococci group A. In a randomized, controlled and single blind multicentre study 206 patients older than 5 years with a positive culture of group A streptococci were treated with phenoxymethylpenicillin for 7 days. 101 patients received the daily dosage divided in 2 doses and 105 patients divided in 3 doses a day. The cure rate (a combination of bacteriological and clinical cure) was 82.0% in the 2-dosage regimen, and 88.2% in the 3-dosage regimen. The difference was not statistically significant. In conclusion, phenoxymethylpenicillin dosed 2 or 3 times daily seems to be equally effective in tonsillitis due to group A streptococci.
AuthorsG Fyllingen, A R Arnesen, C Biermann, O Kaarby, O Romfo, J Rønnevig, J Aaserud
JournalScandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 23 Issue 5 Pg. 553-8 ( 1991) ISSN: 0036-5548 [Print] SWEDEN
PMID1767251 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Penicillin V
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Norway
  • Penicillin V (administration & dosage, therapeutic use)
  • Single-Blind Method
  • Streptococcal Infections (drug therapy, microbiology)
  • Streptococcus pyogenes
  • Tonsillitis (diagnosis, drug therapy, microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: