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Phenoxymethylpenicillin two or three times daily for tonsillitis with beta-haemolytic streptococci group A: a blinded, randomized and controlled clinical study.

Abstract
In relation to compliance problems it was investigated whether phenoxymethylpenicillin dosed twice or 3 times daily was equally effective in tonsillitis due to beta-haemolytic streptococci group A. In a randomized, controlled and single blind multicentre study 206 patients older than 5 years with a positive culture of group A streptococci were treated with phenoxymethylpenicillin for 7 days. 101 patients received the daily dosage divided in 2 doses and 105 patients divided in 3 doses a day. The cure rate (a combination of bacteriological and clinical cure) was 82.0% in the 2-dosage regimen, and 88.2% in the 3-dosage regimen. The difference was not statistically significant. In conclusion, phenoxymethylpenicillin dosed 2 or 3 times daily seems to be equally effective in tonsillitis due to group A streptococci.
AuthorsG Fyllingen, A R Arnesen, C Biermann, O Kaarby, O Romfo, J Rønnevig, J Aaserud
JournalScandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 23 Issue 5 Pg. 553-8 ( 1991) ISSN: 0036-5548 [Print] SWEDEN
PMID1767251 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Penicillin V
Topics
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Norway
  • Penicillin V (administration & dosage, therapeutic use)
  • Single-Blind Method
  • Streptococcal Infections (drug therapy, microbiology)
  • Streptococcus pyogenes
  • Tonsillitis (diagnosis, drug therapy, microbiology)

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