Abstract |
Despite significant advances in our understanding of the molecular structure and composition of the glomerular filtration barrier, the mechanisms underlying the presence of excess protein in the urine ( proteinuria) in acquired human kidney diseases remain elusive. In a study appearing in this issue of the JCI, Sever and associates use a combination of biochemical, genetic, and in vivo approaches in mice to demonstrate a pivotal role of cathepsin L and its substrate the GTPase dynamin, in the induction of proteinuria and associated foot process effacement in glomerular podocytes (see the related article beginning on page 2095).
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Authors | Pierre Ronco |
Journal | The Journal of clinical investigation
(J Clin Invest)
Vol. 117
Issue 8
Pg. 2079-82
(Aug 2007)
ISSN: 0021-9738 [Print] United States |
PMID | 17671644
(Publication Type: Journal Article, Comment)
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Chemical References |
- Actins
- Cathepsins
- Cysteine Endopeptidases
- CTSL protein, human
- Cathepsin L
- Ctsl protein, mouse
- Dynamins
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Topics |
- Actins
(genetics, metabolism)
- Animals
- Cathepsin L
- Cathepsins
(genetics, metabolism)
- Cells, Cultured
- Cysteine Endopeptidases
(genetics, metabolism)
- Cytoskeleton
(genetics, metabolism, pathology)
- Dynamins
(genetics, metabolism)
- Kidney Diseases
(enzymology, genetics, pathology)
- Mice
- Mutation
- Podocytes
(enzymology, pathology)
- Proteinuria
(genetics, metabolism, pathology)
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