Abstract | PURPOSE: EXPERIMENTAL DESIGN: RESULTS:
Flavopiridol caused a > or =50% decrease in peripheral blood blasts in 44% by median day 2 and > or =80% decrease in 26% by day 3. Self-limited tumor lysis occurred in 53%. Three (5%) died during therapy (2 multiorgan failure and 1 fungal pneumonia). Complete remissions (CR) were achieved in 12 of 15 (75%) newly diagnosed secondary AML, 18 of 24 (75%) first relapse after short CR (median CR, 9 months, including prior allotransplant), and 2 of 13 (15%) primary refractory but 0 of 10 multiply refractory AML. Disease-free survival for all CR patients is 40% at 2 years, with newly diagnosed patients having a 2-year disease-free survival of 50%. CONCLUSIONS:
Flavopiridol has anti-AML activity directly and in combination with ara-C and mitoxantrone. This timed sequential regimen induces durable CRs in a significant proportion of adults with newly diagnosed secondary AML (including complex cytogenetics) and adults with AML in first relapse after short first CR.
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Authors | Judith E Karp, B Douglas Smith, Mark J Levis, Steven D Gore, Jacqueline Greer, Catherine Hattenburg, Janet Briel, Richard J Jones, John J Wright, A Dimitri Colevas |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 13
Issue 15 Pt 1
Pg. 4467-73
(Aug 01 2007)
ISSN: 1078-0432 [Print] United States |
PMID | 17671131
(Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Flavonoids
- Piperidines
- Cytarabine
- alvocidib
- Mitoxantrone
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Cytarabine
(administration & dosage)
- Disease-Free Survival
- Female
- Flavonoids
(administration & dosage)
- Humans
- Infusions, Intravenous
- Leukemia, Myeloid, Acute
(drug therapy, pathology)
- Male
- Maximum Tolerated Dose
- Middle Aged
- Mitoxantrone
(administration & dosage)
- Neoplasm Recurrence, Local
(drug therapy, pathology)
- Piperidines
(administration & dosage)
- Prognosis
- Remission Induction
- Salvage Therapy
- Survival Rate
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