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Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice.

Abstract
Epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene (DNFB), evoke an atopic dermatitis (AD)-like dermatitis reaction in NC/Nga mice under specific pathogen free (SPF) conditions. Astragalus membranaceus (AM), is a popular herbal medicine used to treat allergic diseases in East Asia. In the present study, we examined whether AM suppress AD-like skin lesions in NC/Nga mice treated with DNFB under SPF conditions. Oral administration of AM to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Moreover, IFN-gamma production by CD4(+) T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by AM treatment, although levels of IL-4 and total IgE in serum were not. Study findings suggest that AM may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-gamma production.
AuthorsSu-Jin Lee, Seung-Geun Oh, Sang-Wan Seo, Hyun-Jong Ahn, Dongho Geum, Jeong-Je Cho, Cheung-Seog Park
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 30 Issue 8 Pg. 1468-71 (Aug 2007) ISSN: 0918-6158 [Print] Japan
PMID17666805 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Cytokines
  • Interleukin-4
  • Immunoglobulin E
  • Interferon-gamma
  • Prednisolone
  • Dinitrofluorobenzene
Topics
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Astragalus propinquus (chemistry)
  • CD4-Positive T-Lymphocytes (drug effects, metabolism)
  • Cytokines (biosynthesis)
  • Dermatitis, Atopic (chemically induced, prevention & control)
  • Dinitrofluorobenzene (antagonists & inhibitors, toxicity)
  • Ear, External (pathology)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Immunoglobulin E (blood)
  • Interferon-gamma (biosynthesis)
  • Interleukin-4 (biosynthesis)
  • Mice
  • Mice, Inbred Strains
  • Prednisolone (pharmacology)
  • Skin (pathology)

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