Abstract |
Epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene ( DNFB), evoke an atopic dermatitis (AD)-like dermatitis reaction in NC/Nga mice under specific pathogen free (SPF) conditions. Astragalus membranaceus (AM), is a popular herbal medicine used to treat allergic diseases in East Asia. In the present study, we examined whether AM suppress AD-like skin lesions in NC/Nga mice treated with DNFB under SPF conditions. Oral administration of AM to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Moreover, IFN-gamma production by CD4(+) T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by AM treatment, although levels of IL-4 and total IgE in serum were not. Study findings suggest that AM may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-gamma production.
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Authors | Su-Jin Lee, Seung-Geun Oh, Sang-Wan Seo, Hyun-Jong Ahn, Dongho Geum, Jeong-Je Cho, Cheung-Seog Park |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 30
Issue 8
Pg. 1468-71
(Aug 2007)
ISSN: 0918-6158 [Print] Japan |
PMID | 17666805
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Cytokines
- Interleukin-4
- Immunoglobulin E
- Interferon-gamma
- Prednisolone
- Dinitrofluorobenzene
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Astragalus propinquus
(chemistry)
- CD4-Positive T-Lymphocytes
(drug effects, metabolism)
- Cytokines
(biosynthesis)
- Dermatitis, Atopic
(chemically induced, prevention & control)
- Dinitrofluorobenzene
(antagonists & inhibitors, toxicity)
- Ear, External
(pathology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Immunoglobulin E
(blood)
- Interferon-gamma
(biosynthesis)
- Interleukin-4
(biosynthesis)
- Mice
- Mice, Inbred Strains
- Prednisolone
(pharmacology)
- Skin
(pathology)
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