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Pneumococcal surface protein A family types of Streptococcus pneumoniae from community-acquired pneumonia patients in Japan.

Abstract
We assessed pneumococcal surface protein A (PspA) family types of 141 isolates of Streptococcus pneumoniae from community-acquired pneumonia patients in Japan. Families 1 and 2 were expressed in 78 (55.3%) and 58 (41.1%) isolates, respectively. Five isolates were not typed either as family 1 or 2. PspA family types were not associated with age, sex, or pneumonia severity. Penicillin-resistant S. pneumoniae was more likely to belong to family 2 whereas organisms highly resistant to erythromycin and positive for ermB were more prevalent in family 1. The association of PspA type with antimicrobial resistance was possibly affected by prevalent serotypes or resistance clones. It would therefore be necessary to include both family 1 and 2 proteins in a PspA-containing vaccine to cover the major PspA families and to reduce antimicrobial resistance.
AuthorsY Ito, M Osawa, R Isozumi, S Imai, I Ito, T Hirai, T Ishida, S Ichiyama, M Mishima, Kansai Community Acquired Pneumococcal Pneumonia Study Group
JournalEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 26 Issue 10 Pg. 739-42 (Oct 2007) ISSN: 0934-9723 [Print] Germany
PMID17665229 (Publication Type: Journal Article, Multicenter Study)
Chemical References
  • Bacterial Proteins
  • Pneumococcal Vaccines
  • pneumococcal surface protein A
  • Methyltransferases
  • ErmA protein, Bacteria
Topics
  • Aged
  • Aged, 80 and over
  • Bacterial Proteins (genetics, immunology, metabolism)
  • Community-Acquired Infections (epidemiology, immunology, metabolism)
  • Drug Resistance, Multiple, Bacterial (genetics)
  • Electrophoresis, Gel, Pulsed-Field (methods)
  • Female
  • Humans
  • Japan (epidemiology)
  • Male
  • Methyltransferases (genetics)
  • Middle Aged
  • Pneumococcal Vaccines (immunology)
  • Pneumonia, Pneumococcal (epidemiology, immunology, microbiology)
  • Prospective Studies
  • Streptococcus pneumoniae (genetics, isolation & purification, metabolism)

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