Serum IgA class anti-IgA antibody in IgA nephropathy.

Abstract

IgA class anti-IgA antibody was sought by an immunoabsorbent technique in sera from patients with IgA nephropathy (IgA-N, n = 62), other forms of primary glomerulonephritis (PGN, n = 41), seropositive rheumatoid arthritis (RF-positive, n = 18) and normal controls (c, n = 50). IgA-N (31%) and RF-positive (56%) patients showed a significant increase in IgA anti-IgA antibody levels. The subclass of IgA anti-IgA antibody was predominantly IgA1 in both IgA-N and RF-positive patients. Size analysis revealed the dimer/monomer ratio to be significantly increased in IgA-N patients compared with that of RF-positive patients (p = 0.03). These results indicate the possible existence of the dimeric form of IgA class anti-IgA antibody in the circulation of IgA-N patients.

• Authors: Y Hiki, M Saitoh, Y Kobayashi
• Journal: Nephron (Nephron) Vol. 59 Issue 4 Pg. 552-60 ( 1991) ISSN: 1660-8151 [Print] Switzerland
• PMID: 1766493 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Anti-Idiotypic
• Immunoglobulin A
• Immunoglobulin G
• Immunoglobulin M
• Rheumatoid Factor

Topics

• Antibodies, Anti-Idiotypic (blood, chemistry, classification)
• Antibody Specificity
• Glomerulonephritis, IGA (immunology)
• Humans
• Immunoglobulin A (chemistry, classification, metabolism)
• Immunoglobulin G
• Immunoglobulin M
• Rheumatoid Factor (blood)