Altered urinary release of inositol phosphoglycan A-type in women with gestational diabetes mellitus.

Abstract

BACKGROUND/AIMS:

The mechanisms underlying overgrowth of adipose tissue in fetuses of women with gestational diabetes mellitus (GDM) are generally unknown. Inositol phosphoglycan A-type (A-IPG), a putative second messenger of insulin, was reported to regulate lipogenesis in adipose tissue. IPGs have recently been shown to increase during normal pregnancy, in maternal and fetal compartments.

METHODS:

48 women with GDM and 23 healthy pregnant women were recruited for this cross-sectional study. Levels of A-IPG were assessed enzymatically in urinary specimens and correlated with clinical parameters.

RESULTS:

A-IPG urinary release was lower in GDM patients (p < 0.01) and correlated positively with BMI (p < 0.01) and negatively with glycaemic control in the diabetic group (postprandial glycaemia and glycated haemoglobin, p < 0.01) in addition to a nearly significant correlation with birth weight (p = 0.08). Furthermore, a lower A-IPG urinary release was found in diabetic subjects with normal fasting glycaemia compared with those with poor fasting glycaemic control (p < 0.05).

CONCLUSIONS:

An altered A-IPG urinary excretion occurs in GDM with a negative correlation with poor glycaemic control. Our data suggest an interesting potential role of this molecule in maternal metabolic control during pregnancy and, possibly, in fetal growth.

• Authors: Marco Scioscia, Sirilaksana Kunjara, Khalid Gumaa, Antonio M Gomez Galan, Patricia McLean, Charles H Rodeck, Thomas W Rademacher
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 64 Issue 4 Pg. 217-23 ( 2007) ISSN: 1423-002X [Electronic] Switzerland
• PMID: 17664885 (Publication Type: Journal Article)
• Copyright: 2007 S. Karger AG, Basel

Chemical References

• Blood Glucose
• Inositol Phosphates
• Polysaccharides
• inositol phosphate glycan

Topics

• Adult
• Blood Glucose
• Body Mass Index
• Case-Control Studies
• Cross-Sectional Studies
• Diabetes, Gestational (urine)
• Female
• Glucose Tolerance Test
• Glycemic Index
• Humans
• Inositol Phosphates (urine)
• Polysaccharides (urine)
• Pregnancy