[Effect of arterial carbon dioxide tension on regional myocardial tissue oxygen tension in the dog].

Abstract

We investigated the effects of arterial carbon dioxide tension on the myocardial tissue oxygen tensions of subepicardium and subendocardium in the anesthetized dogs. The study was done in fourteen open-chest mongrel dogs, weighing 13 +/- 1 kg, anesthetized with sodium pentobarbital (30 mg.kg-1 iv), and mechanically ventilated with 100% oxygen to maintain normocapnia. End tidal CO2 fraction (FECO2) was monitored continuously by capnograph. Regional myocardial tissue PO2 was measured using a monopolar polarographic needle electrode. Two pairs of combined needle sensors were carefully inserted, one in the epicardial and the other in the endocardial layer of the beating heart. Electromagnetic blood flow probe was applied on the left anterior descending artery (LAD). After a stable normocapnic ventilation, hypocapnia was induced by increasing the respiratory rate, and this mechanical hyperventilation was kept fixed throughout the experiments. To induce hypercapnia, exogenous carbon dioxide was added to the inspired gas step-wise until FECO2 reached 10%. Hypocapnic hyperventilation (PaCO2: 22 mmHg) invariably resulted in a significant reduction of coronary blood flow (LADBF) and left ventricular myocardial tissue PO2 in both epicardial and endocardial layers, while addition of carbon dioxide to the inspired gas (hypercapnic hyperventilation) reversed the change by increased LADBF and arterial PaCO2 in a dose-dependent manner. These results indicate that injudicious and severe hypocapnic hyperventilation may induce impaired myocardial tissue perfusion and oxygenation although normal cardiac output and arterial blood oxygenation are maintained.

• Authors: K Okazaki, K Hashimoto, Y Okutsu, F Okumura
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 40 Issue 11 Pg. 1620-4 (Nov 1991) ISSN: 0021-4892 [Print] Japan
• PMID: 1766112 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carbon Dioxide
• Oxygen

Topics

• Animals
• Arteries
• Carbon Dioxide (blood)
• Dogs
• Myocardium (metabolism)
• Oxygen (metabolism)
• Partial Pressure