Abstract | BACKGROUND: MATERIAL/METHODS: Male ZDF (Gmi fa/fa) rats and their littermates (Gmi +/+), aged 8 weeks, were randomly assigned in two groups: an exercise trained and a sedentary one. Swimming was conducted 1 h/day 3 days/week for 12 weeks. The rats were sacrificed 48 h after the last round of exercise. Rats had their body weight, insulin, adiponectin, CRP, as well as glucose, total cholesterol, triglycerides, MDA, and SOD measured and HOMA-IR calculated before and after the 12-week swimming training. RESULTS: In the ZDF (fa/fa) rats underwent swimming exercise, all the metabolic abnormalities were totally or partially prevented (p<0.001), namely the hyperglycemic, hyperinsulinemic, and dyslipidemic pattern observed in their sedentary counterparts. Furthermore, even without body weight change, a plasma adiponectin increase (28.0%) and a CRP decrease (12.7%) were also observed. CONCLUSIONS: A 12-week thrice-weekly swimming training was associated with improved measures of chronic inflammation markers as measured by adiponectin and CRP. Moreover, improvements in insulin sensitivity resulting from swimming exercise appeared to be related to changes in these inflammatory mediators.
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Authors | Edite Teixeira de Lemos, Flávio Reis, Sofia Baptista, Rui Pinto, Bruno Sepodes, Helena Vala, Petronila Rocha-Pereira, Alice Santos Silva, Frederico Teixeira |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 13
Issue 8
Pg. BR168-74
(Aug 2007)
ISSN: 1234-1010 [Print] United States |
PMID | 17660720
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Malondialdehyde
- C-Reactive Protein
- Superoxide Dismutase
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Topics |
- Adiponectin
(blood, physiology)
- Animals
- Animals, Genetically Modified
- C-Reactive Protein
(biosynthesis, physiology)
- Diabetes Mellitus, Experimental
(metabolism, therapy)
- Diabetes Mellitus, Type 2
(metabolism, therapy)
- Inflammation
- Male
- Malondialdehyde
(blood)
- Physical Conditioning, Animal
- Rats
- Rats, Zucker
- Superoxide Dismutase
(blood)
- Swimming
- Time Factors
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