Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy.
Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: To identify the effect of FXR activation in modulation of diabetic nephropathy, we treated 1) C57BL/6J mice on low-fat diet or high-fat diet with FXR agonists ( GW4064 or cholic acid) for 1 week; 2) C57BLKS/J-db/db mice and their lean mates with GW4064 for 1 week; and 3) C57BL/6J-db/db mice and their lean mates with cholic acid for 12 weeks. RESULTS: CONCLUSIONS: These results therefore indicate a new and important role for FXR in the kidney and provide new therapeutic avenues for the treatment of diabetic nephropathy.
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Authors | Tao Jiang, Xiaoxin X Wang, Pnina Scherzer, Paul Wilson, James Tallman, Hideaki Takahashi, Jinping Li, Mieko Iwahashi, Eileen Sutherland, Lois Arend, Moshe Levi |
Journal | Diabetes
(Diabetes)
Vol. 56
Issue 10
Pg. 2485-93
(Oct 2007)
ISSN: 1939-327X [Electronic] United States |
PMID | 17660268
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- DNA-Binding Proteins
- Dietary Fats
- Lipids
- Receptors, Cytoplasmic and Nuclear
- Srebf1 protein, mouse
- Sterol Regulatory Element Binding Protein 1
- Transcription Factors
- farnesoid X-activated receptor
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Topics |
- Animals
- DNA-Binding Proteins
(agonists, physiology)
- Diabetic Nephropathies
(physiopathology)
- Diet, Fat-Restricted
- Dietary Fats
- Fibrosis
- Inflammation
- Kidney
(metabolism, pathology)
- Lipids
(physiology)
- Mice
- Mice, Inbred C57BL
- Receptors, Cytoplasmic and Nuclear
(agonists, physiology)
- Sterol Regulatory Element Binding Protein 1
(physiology)
- Transcription Factors
(agonists, physiology)
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