Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage.

Abstract	Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression.
Authors	Heather L LaMarca, Jeffrey M Rosen
Journal	Breast cancer research : BCR (Breast Cancer Res) Vol. 9 Issue 4 Pg. 304 ( 2007) ISSN: 1465-542X [Electronic] England
PMID	17659070 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	AREG protein, human Amphiregulin EGF Family of Proteins Estrogens Glycoproteins Intercellular Signaling Peptides and Proteins
Topics	Amphiregulin Breast (growth & development, pathology) Breast Neoplasms (etiology, pathology) EGF Family of Proteins Estrogens (pharmacology) Glycoproteins (metabolism) Humans Intercellular Signaling Peptides and Proteins (metabolism)

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