[Metaiodobenzylguanidine scintigraphy in the diagnosis and followup of neuroblastoma. Apropos of 16 cases].

The aim of this study is to evaluate meta-iodo-benzyl-guanidine scintigraphy in the diagnosis and the management of neuroblastoma.
betwen september 1999 and jun 2004, 16 children aging from 4 months to 6 years, with neuroblastoma, underwent mIBG scintigraphy in military hospital nuclear medicine department.
23 mIBG scans were done. The exam was indicated for the initial staging in 7 cases, to evaluate chemotherapy or surgery in 12 cases and to seek for reccurences in 3 cases. The sensitivity of mIBG was 57% in the detection of the primary tumor, 100% for liver metastases and 67% for medullar involvement.
mIBG scintigraphy should be a standard in the initial staging of neuroblastoma and in evaluating therapy response.
AuthorsHatem Hammami, Latifa Hassine, Aida Mhiri, Ali Sellem, Fayçal Oubich, Lamia Gharssallah, Sihem Barsaoui, Habib Ben Brahim
JournalLa Tunisie meĢdicale (Tunis Med) Vol. 85 Issue 5 Pg. 413-6 (May 2007) ISSN: 0041-4131 [Print] Tunisia
Vernacular TitleLa scintigraphie à la méta-iodo-benzyl-guanidine dans le diagnostic et le suivi des neuroblastomes. A propos de 16 cas.
PMID17657930 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Radiopharmaceuticals
  • 3-Iodobenzylguanidine
  • 3-Iodobenzylguanidine
  • Abdominal Neoplasms (drug therapy, radionuclide imaging, surgery)
  • Antineoplastic Agents (therapeutic use)
  • Bone Marrow Neoplasms (radionuclide imaging, secondary)
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Liver Neoplasms (radionuclide imaging, secondary)
  • Male
  • Neoplasm Recurrence, Local (radionuclide imaging)
  • Neoplasm Staging
  • Neuroblastoma (drug therapy, radionuclide imaging, surgery)
  • Radiopharmaceuticals
  • Retrospective Studies
  • Sensitivity and Specificity

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