Drug insight: advances in renal cell carcinoma and the role of targeted therapies.

In metastatic renal cell carcinoma (RCC) immunotherapy results in a small but important improvement in overall survival, but a need exists to develop more-effective systemic therapies. Recent developments in our understanding of the molecular biology of RCC have identified several pathways associated with the development of the disease. A number of strategies designed specifically to target these pathways have resulted. Initial studies have shown marked clinical benefits of so-called 'targeted therapies'. Sunitinib, sorafenib and axitinib are kinase inhibitors that inhibit the VEGF, platelet-derived growth factor and c-kit receptor tyrosine kinases. Bevacizumab is a monoclonal antibody that is directed against VEGF. Temsirolimus inhibits the mammalian target of rapamycin. These agents have all shown considerable activity with manageable toxicity in phase II and III studies in both previously treated and untreated patients. In phase III studies, sorafenib and bevacizumab have been associated with prolonged progression-free survival compared with placebo. Phase III data have shown improvements in progression-free and overall survival with sunitinib and temsirolimus, respectively, compared with interferon alfa. Additional studies are needed to determine the optimum utilization of these agents at the appropriate stage of disease and in the best combinations for maximal clinical benefit.
AuthorsJames M G Larkin, Simon Chowdhury, Martin E Gore
JournalNature clinical practice. Oncology (Nat Clin Pract Oncol) Vol. 4 Issue 8 Pg. 470-9 (Aug 2007) ISSN: 1743-4262 [Electronic] England
PMID17657252 (Publication Type: Journal Article, Review)
Chemical References
  • Protein Kinase Inhibitors
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Carcinoma, Renal Cell (drug therapy)
  • Clinical Trials as Topic
  • Humans
  • Kidney Neoplasms (drug therapy)
  • Protein Kinase Inhibitors (therapeutic use)
  • Signal Transduction

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: