Abstract | OBJECTIVE: METHODS: All the cases of clinically diagnosed pulmonary fungal infection from January 2002 to June 2006 were reevaluated according to the definitions of European Organization for Research and Treatment of Cancer/National Institute of Allergy and Infectious Diseases Mycosis Study Group (EORTC/ MSG), and the etiology of the patients were analyzed. RESULTS:
Pulmonary fungal disease was classified as proven (n = 38), probable (n = 24), possible (n = 35) and colonization (n = 55). In the proven group, the most frequently encountered fungi were Aspergillus species (15/38), followed by Cryptococcus species (13/38), Candida species were rare (2/38). In the probable group, Aspergillus species and Aspergillus species + Candida species were among the most common pathogens; while in the possible group and the colonization group, Candida species were most frequently encountered. The mortality of patients with probable pulmonary fungal infection (58.3%) was higher than that of patients in the possible group (25.7%) or the colonization group (16.4%) (P = 0.001). Univariate analysis showed that only APACHE II score was associated with outcome of patients with "pulmonary Candida infections", and antifungal therapy did not improve the outcome of such patients. CONCLUSION: The most frequently encountered fungi in patients with pulmonary fungal infections were Aspergillus species, followed by Cryptococcus species. Primary Candida pulmonary infections were rare.
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Authors | Bin Cao, Bai-Qiang Cai, Hui Wang, Chao-Yang Zhou, Peng Wang, Hong-Rui Liu, Hong Zhang, Ling Xu, Kai-Feng Xu, Wen-Bing Xu, Yuan-Jue Zhu, Xiao-Guang Li |
Journal | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
(Zhonghua Jie He He Hu Xi Za Zhi)
Vol. 30
Issue 4
Pg. 279-83
(Apr 2007)
ISSN: 1001-0939 [Print] China |
PMID | 17651612
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aspergillosis
(diagnosis)
- Aspergillus
(isolation & purification)
- Candida
(isolation & purification)
- Candidiasis
(diagnosis)
- Cryptococcosis
(diagnosis)
- Cryptococcus
(isolation & purification)
- Female
- Humans
- Lung Diseases, Fungal
(classification, diagnosis, microbiology)
- Middle Aged
- Young Adult
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