[Effects of Shengqi Jiangtang Granule on rat model of insulin resistance and its mechanism].

Abstract

OBJECTIVE:

To study the effect of Shengqi Jiangtang Granule (SJG) on rat model of insulin resistance (IR) and explore the mechanism.

METHODS:

IR model was induced by high fat diet and peritoneal injection of streptozotocin in Wistar rats. Model rats were randomly divided into the model group, the low, medium and high dose SJG groups treated with corresponding dose of SJG, and thc RGL group with rosiglitazone (RGL). A normal control group was also set up. Blood glucose (BG), protein expression of endothelin-1 (ET-1) and protein kinase C (PKC) in aortic tissue were detected.

RESULTS:

BG decreased in the high and medium dose SJG groups and the RGL group after treatment, and the lowest level was shown in the high dose SJG group. Compared with that in the normal group, the expressions of ET-1 and PKC obviously increased in the model group (P<0.05), which was lowered in the RGL group and the high and medium dose SJG groups after treatment in a dosage-depending manner, showing significant difference to those in the model group (P < 0.05).

CONCLUSION:

SJG can lower blood glucose and inhibit ET-1 and PKC expressions to improve vascular endothelial function, thus to promote insulin sensitiveness and alleviate IR.

• Authors: Yong Li, Meng-Yu Liu, Yan-Gang Wang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 27 Issue 5 Pg. 449-51 (May 2007) ISSN: 1003-5370 [Print] China
• PMID: 17650802 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Drugs, Chinese Herbal
• Endothelin-1
• Hypoglycemic Agents
• Thiazolidinediones
• shengqi jiangtang
• Rosiglitazone
• Protein Kinase C

Topics

• Animals
• Blood Glucose (metabolism)
• Diabetes Mellitus, Experimental (blood, drug therapy, physiopathology)
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Endothelin-1 (metabolism)
• Hypoglycemic Agents (therapeutic use)
• Insulin Resistance
• Male
• Phytotherapy
• Protein Kinase C (metabolism)
• Random Allocation
• Rats
• Rats, Wistar
• Rosiglitazone
• Thiazolidinediones (therapeutic use)
• Treatment Outcome