[Clinical study on toxicity-attenuation effect of Yiguan Decoction in treatment of non-small cell lung cancer with NP protocol of chemotherapy].

Abstract

OBJECTIVE:

To observe the toxicity-attenuation effect of Yiguan Decoction (YGD) in treatment of non-small cell lung cancer (NSCLC) with NP protocol of chemotherapy.

METHODS:

Ninety-two NSCLC patients were randomly assigned to two groups equally, the control group given only NP protocol of chemotherapy and the treated group given the same protocol of chemotherapy plus YGD. Hepatic function, T-cell subgroup and NK cell were examined, and quality of life (QOL) was evaluated with scoring by Karnofsky performance status (KPS), Quality of Life Questionnaire-Core30 (EORTC QLQ-C30) and Special Scale for lung cancer (EORTC LC13) issued by European Organization for Research and Treatment of Cancer.

RESULTS:

The effects on all the above-mentioned indexes in the treated group were better than those in the control group after 42 days of treatment (P <0.05).

CONCLUSION:

YGD could not only reduce the side and toxic effects caused by NP protocol of chemotherapy in NSCLC patients but also improve their QOL.

• Authors: Ting Zhang, Sheng-Lin Ma, Jian-Hua Yue
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 27 Issue 5 Pg. 396-9 (May 2007) ISSN: 1003-5370 [Print] China
• PMID: 17650789 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Drugs, Chinese Herbal
• yiguan
• Cisplatin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Carcinoma, Non-Small-Cell Lung (drug therapy)
• Cisplatin (administration & dosage)
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Humans
• Lung Neoplasms (drug therapy)
• Male
• Middle Aged
• Phytotherapy
• Quality of Life
• Treatment Outcome