Abstract | AIMS: METHODS AND RESULTS: Thirteen cases with the histological changes of NSM, eight SCCs and eight MECs were examined with the following immunohistochemical markers: calponin, S100, smooth muscle actin (SMA), p63, CK7, CK5, CK6 and CAM5.2. The distribution and intensity of staining were recorded. Residual myoepithelial cells (best demonstrated by calponin and SMA) were identified at the periphery of the epithelial islands in all cases of NSM (although not in all islands), in contrast to MEC and SCC. S100 showed a similar pattern, although staining fewer cells. Moderate rather than extensive expression of CK7 may help to distinguish NSM from MEC. CONCLUSION: Identification of myoepithelial cells and CK7 expression may help to distinguish NSM from its mimics.
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Authors | H Rizkalla, M Toner |
Journal | Histopathology
(Histopathology)
Vol. 51
Issue 2
Pg. 184-9
(Aug 2007)
ISSN: 0309-0167 [Print] England |
PMID | 17650214
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Actins
- Biomarkers
- Biomarkers, Tumor
- CAM 5.2 antigen
- CKAP4 protein, human
- Calcium-Binding Proteins
- Keratins, Type II
- Membrane Proteins
- Microfilament Proteins
- S100 Proteins
- calponin
- Keratins
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Topics |
- Actins
(metabolism)
- Biomarkers
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Calcium-Binding Proteins
(metabolism)
- Carcinoma, Mucoepidermoid
(diagnosis, metabolism, pathology)
- Carcinoma, Squamous Cell
(diagnosis, metabolism, pathology)
- Diagnosis, Differential
- Head and Neck Neoplasms
(diagnosis, metabolism, pathology)
- Humans
- Immunohistochemistry
- Keratins
(metabolism)
- Keratins, Type II
(classification, metabolism)
- Membrane Proteins
(metabolism)
- Microfilament Proteins
(metabolism)
- S100 Proteins
(metabolism)
- Sialometaplasia, Necrotizing
(diagnosis, metabolism, pathology)
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