Abstract | BACKGROUND: OBJECTIVES: METHODS: Several experiments were performed in B16 melanoma cells. We studied melanin content, tyrosinase activity and cAMP production, and performed cAMP response element (CRE) luciferase reporter assay and Western blots for proteins involved in melanogenesis. RESULTS: CONCLUSIONS: Our study shows that DMHF inhibits alpha-MSH-induced melanogenesis by suppressing CREB phosphorylation, which is induced by protein kinase A, and suggests that DMHF may be an effective inhibitor of hyperpigmentation.
|
Authors | J Lee, E Jung, J Lee, S Huh, Y C Boo, C G Hyun, Y-S Kim, D Park |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 157
Issue 2
Pg. 242-8
(Aug 2007)
ISSN: 0007-0963 [Print] England |
PMID | 17650175
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Cyclic AMP Response Element-Binding Protein
- Furans
- Melanins
- Microphthalmia-Associated Transcription Factor
- furaneol
- alpha-MSH
- Cyclic AMP
- Oxidoreductases
- tyrosinase-related protein-1
- Monophenol Monooxygenase
|
Topics |
- Animals
- Cyclic AMP
(biosynthesis)
- Cyclic AMP Response Element-Binding Protein
(metabolism)
- Furans
(pharmacology)
- Humans
- Melanins
(biosynthesis)
- Melanocytes
(drug effects, metabolism)
- Melanoma, Experimental
(metabolism, pathology)
- Microphthalmia-Associated Transcription Factor
(biosynthesis)
- Monophenol Monooxygenase
(biosynthesis, metabolism)
- Oxidoreductases
(biosynthesis)
- Tumor Cells, Cultured
- alpha-MSH
(antagonists & inhibitors, pharmacology)
|