Abstract | BACKGROUND: METHODS: RESULTS: Twenty-four hours after the initiation of the drug infusion, patients treated with levosimendan (n=11) showed a significant reduction of the isovolumetric relaxation time (116+/-15.2-70.4+/-10.8 ms; P<.001), and a significant increase of the E/A ratio (0.6+/-0.3-1.4+/-0.5; P<.001). In the dobutamine group (n=11), no statistically significant differences were noted in the echocardiographic Doppler indexes. CONCLUSION:
Levosimendan seems to be effective in improving the Doppler echocardiographic parameters of LV diastolic function in patients with STEMI revascularised by primary PCI who developed cardiogenic shock.
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Authors | Alberto Dominguez-Rodriguez, Sima Samimi-Fard, Martin J Garcia-Gonzalez, Pedro Abreu-Gonzalez |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 128
Issue 2
Pg. 214-7
(Aug 18 2008)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 17643535
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Cardiotonic Agents
- Hydrazones
- Pyridazines
- Simendan
- Dobutamine
|
Topics |
- Angioplasty, Balloon, Coronary
(adverse effects)
- Cardiotonic Agents
(administration & dosage, pharmacology)
- Diastole
- Dobutamine
(administration & dosage, pharmacology)
- Echocardiography, Doppler
- Female
- Humans
- Hydrazones
(administration & dosage, pharmacology)
- Infusions, Intravenous
- Male
- Middle Aged
- Pyridazines
(administration & dosage, pharmacology)
- Shock, Cardiogenic
(diagnostic imaging, drug therapy, etiology)
- Simendan
- Ventricular Function, Left
(drug effects)
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