Urinary eosinophil protein X in children with atopic asthma.

Abstract

UNLABELLED:

The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in asthmatic school children.

METHODS:

A cross-sectional study was performed in 180 steroid dependent atopic children with stable moderately severe asthma, who were stable on 200 or 500 microg of fluticasone per day. uEPX was measured in a single sample of urine and was normalized for creatinine concentration (uEPX/c). Symptom scores were kept on a diary card. FEV1 and PD20 methacholine were measured. Sputum induction was performed in 49 and FE(NO) levels measured in 24 children.

RESULTS:

We found an inverse correlation between uEPX/c and FEV1 (r = -.20, P = .01) and a borderline significant correlation between uEPX/c and PD20 methacholine (r = -.15, P = .06). Symptom score, %eosinophils and ECP in induced sputum and FE(NO) levels did not correlate with uEPX/c.

CONCLUSION:

uEPX/c levels did not correlate with established markers of asthma severity and eosinophilic airway inflammation in atopic asthmatic children.

• Authors: M Nuijsink, W C J Hop, P J Sterk, E J Duiverman, P S Hiemstra, J C de Jongste, CATO Study Group
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2007 Pg. 49240 ( 2007) ISSN: 1466-1861 [Electronic] United States
• PMID: 17641730 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Androstadienes
• Creatinine
• Fluticasone
• Eosinophil-Derived Neurotoxin

Topics

• Adolescent
• Androstadienes (therapeutic use)
• Asthma (drug therapy, pathology, urine)
• Child
• Creatinine (urine)
• Cross-Sectional Studies
• Eosinophil-Derived Neurotoxin (urine)
• Eosinophils (metabolism)
• Female
• Fluticasone
• Humans
• Male
• Sputum (metabolism)