COX-1 and -2 activity of rose hip.

Abstract

The objective of this study was to investigate whether the clinically observed efficacy of rose hip in the treatment of osteoarthritis is due to inhibition of cyclooxygenase-1 and -2. Water, methanol, dichloromethane and hexane extracts of rose hip were tested for in vitro COX-1 and 2 activity. The organic solvent extracts showed good inhibition of both COX-1 and 2. The methanol extract was most active in both assays with IC(50) values of 12 microg/mL for COX-1 and 19 microg/mL for COX-2. The clinically observed effect might be due to inhibition of cyclooxygenase.

• Authors: A K Jäger, I M S Eldeen, J van Staden
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 21 Issue 12 Pg. 1251-2 (Dec 2007) ISSN: 0951-418X [Print] England
• PMID: 17639563 (Publication Type: Journal Article)
• Copyright: Copyright (c) 2007 John Wiley & Sons, Ltd.

Chemical References

• Cyclooxygenase 2 Inhibitors
• Plant Extracts

Topics

• Cyclooxygenase 2 Inhibitors (analysis)
• Fruit (chemistry)
• Osteoarthritis (drug therapy)
• Phytotherapy
• Plant Extracts (chemistry, therapeutic use)
• Rosa (chemistry)