Three new cytotoxic Diels-Alder-type adducts from Morus australis.

Abstract

Three new natural products, australisines A-C (1-3, resp.), were isolated from the stem bark of Morus australis, together with eight related compounds, including mulberrofurans E-G, J, and Q, mongolicin C, chalcomoracin, and kuwanon G. Their structures were fully characterized by spectroscopic methods. Compounds 1-3, mulberrofuran G, mongolicin C, and chalcomoracin showed moderate cytotoxic activities against five human cancer cell lines, with IC50 values ranging from 4.6-9.2 microg/ml, as determined by MTT assay.

• Authors: Qing-Jian Zhang, Yan-Bo Tang, Ruo-Yun Chen, De-Quan Yu
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 4 Issue 7 Pg. 1533-40 (Jul 2007) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 17638335 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytotoxins
• Diels-Alder ribozyme
• Plant Extracts
• RNA, Catalytic

Topics

• Cell Line, Tumor
• Cytotoxins (isolation & purification, toxicity)
• Humans
• Morus
• Plant Bark
• Plant Extracts (isolation & purification, toxicity)
• Plant Stems
• RNA, Catalytic (toxicity)