Abstract |
The treatment of patients with human immunodeficiency virus ( HIV) infection and hemophilia involves unique challenges that may be addressed with novel antiretroviral classes. We describe the safety and efficacy of enfuvirtide therapy in 4 patients with severe hemophilia A. Although local skin reactions were common, neither local nor systemic bleeding worsened. Three patients achieved undetectable HIV loads with enfuvirtide salvage regimens.
|
Authors | Mark N Polizzotto, Alison M Street, Edwina Wright |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 45
Issue 4
Pg. e39-41
(Aug 15 2007)
ISSN: 1537-6591 [Electronic] United States |
PMID | 17638184
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- HIV Envelope Protein gp41
- HIV Fusion Inhibitors
- Peptide Fragments
- Enfuvirtide
|
Topics |
- Adult
- Enfuvirtide
- HIV Envelope Protein gp41
(adverse effects, therapeutic use)
- HIV Fusion Inhibitors
(adverse effects, therapeutic use)
- HIV Infections
(complications, drug therapy)
- Hemophilia A
(complications)
- Humans
- Male
- Middle Aged
- Peptide Fragments
(adverse effects, therapeutic use)
|