Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome.

Abstract

BACKGROUND:

Genetic variation at the apolipoprotein A-V locus, recently discovered proximal to the APOA1/C3/A4 gene cluster, is associated with elevated triglyceride concentrations, a risk factor for atherosclerosis.

METHODS:

The goal of our study was to determine the association of two apolipoprotein A-V (APOA5) gene polymorphisms in a group of urban Romanian subjects with the prevalence of the metabolic syndrome. For this purpose, we assayed -1.131T>C and c.56C>G polymorphisms for 279 subjects divided into three groups: a control group, a metabolic syndrome group and a cardiovascular disease group. Then we correlated the minor allele frequencies with body mass index and biochemical parameters.

RESULTS:

We obtained higher frequency for -1.131C compared to c.56G alleles, both mainly distributed in overweight subjects. Body mass index and triglyceride levels were higher in -1.131C allele carriers in metabolic syndrome patients, but were not significantly different in c.56G carriers compared to those with the native gene. Metabolic syndrome -1.131C homozygotes presented lower high-density lipoprotein cholesterol and higher glucose levels compared to subjects with the native gene. Total cholesterol, low-density lipoprotein cholesterol and insulin were not different between -1.131C or c.56G allele carriers and those with the native gene.

CONCLUSIONS:

Our results demonstrate an independent risk for -1.131T>C APOA5 gene polymorphisms in the development of metabolic syndrome.

• Authors: Loredan Stefan Niculescu, Jamila Fruchart-Najib, Jean-Charles Fruchart, Anca Sima
• Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 45 Issue 9 Pg. 1133-9 ( 2007) ISSN: 1434-6621 [Print] Germany
• PMID: 17635078 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• APOA5 protein, human
• Apolipoprotein A-V
• Apolipoproteins A
• Insulin
• Triglycerides
• Cholesterol

Topics

• Alleles
• Apolipoprotein A-V
• Apolipoproteins A (genetics, physiology)
• Atherosclerosis (genetics)
• Cardiovascular Diseases (genetics)
• Cholesterol (metabolism)
• Gene Frequency
• Genetic Variation
• Homozygote
• Humans
• Insulin (metabolism)
• Metabolic Syndrome (genetics)
• Multigene Family
• Obesity (genetics)
• Polymorphism, Genetic
• Risk Factors
• Triglycerides (metabolism)