Abstract | OBJECTIVE: There is increasing interest in the study of the antioxidant actions of plant phenolic compounds as evidence shows that consumption of plant products rich in these compounds contributes to protection from a number of ailments including cardiovascular diseases. In the present study, the antioxidant effects of selected phenolic compounds from dietary sources, namely barbaloin, 6-gingerol and rhapontin, were investigated. METHODS:
Low-density lipoprotein ( LDL), erythrocytes and erythrocyte membranes were subjected to several in vitro oxidative systems. The antioxidant effects of the phenolic compounds were assessed by their abilities in inhibiting hemolysis and lipid peroxidation of LDL and erythrocyte membranes, and in protecting ATPase activities and protein sulfhydryl groups of erythrocyte membranes. RESULTS: CONCLUSIONS: In view of their protective effects on LDL and erythrocytes against oxidative damage, these phenolic compounds might have potential applications in prooxidant state-related cardiovascular disorders.
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Authors | Rosanna Y Y Lam, Anthony Y H Woo, Po-Sing Leung, Christopher H K Cheng |
Journal | Journal of the American College of Nutrition
(J Am Coll Nutr)
Vol. 26
Issue 3
Pg. 233-42
(Jun 2007)
ISSN: 0731-5724 [Print] United States |
PMID | 17634168
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amidines
- Anthracenes
- Antioxidants
- Catechols
- Fatty Alcohols
- Lipoproteins, LDL
- Phenols
- Stilbenes
- barbaloin
- 2,2'-azobis(2-amidinopropane)
- gingerol
- rhapontin
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Topics |
- Amidines
- Animals
- Anthracenes
(pharmacology)
- Antioxidants
(pharmacology)
- Cardiovascular Diseases
(prevention & control)
- Catechols
- Cells, Cultured
- DNA Damage
- Dose-Response Relationship, Drug
- Erythrocyte Membrane
(drug effects, metabolism)
- Fatty Alcohols
(pharmacology)
- Hemolysis
(drug effects)
- Humans
- Lipid Peroxidation
(drug effects)
- Lipoproteins, LDL
(drug effects)
- Male
- Oxidation-Reduction
- Phenols
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Stilbenes
(pharmacology)
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