[Comparative study on sequential colon dialysis, hemodialysis and peritoneal dialysis in patients with hyperuricemia].

Abstract

OBJECTIVE:

To evaluate the effects of sequential colon dialysis (SCD), hemodialysis (HD) and peritoneal dialysis (PD) on the serum level of uric acid (UA) in patients with hyperuricemia.

METHODS:

A total of 293 patients with mild, moderate and severe degree of hyperuricemia were randomly assigned to three groups according to digital randomized method, and treated with SCD, HD and PD respectively. The serum level of UA was determined with unicase-peroxidase conjugate method, the blood levels of K+, Na+, Cl-, Ca2+ were determined by automatic biochemical analysor, and changes of body weight were measured before and after dialysis.

RESULTS:

In the 293 cases, the three modes of dialysis showed no difference in lowering uric acid in patients of mild degree (P > 0.05). But the HD did show a better efficacy than that of the other two in severe degree patients (P<0.01), while in patients of moderate degree, significant difference (P<0.01) showed between HD and SCD, PD and SCD, but not between HD and PD (P > 0.05). No obvious effect of the various modes of dialysis on the level of K+, Na+, Cl-, Ca2+, body weight.

CONCLUSION:

SCD can decrease the serum level of UA effectively and reduce the incidence of complication of hyperuricemia to some extent, as hemodialysis and peritoneal dialysis can.

• Authors: Hai-tao Wang, Ye Chen, Yuan-hang Huang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 27 Issue 6 Pg. 492-4 (Jun 2007) ISSN: 1003-5370 [Print] China
• PMID: 17633357 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Chlorides
• Drugs, Chinese Herbal
• Uric Acid
• Sodium
• Potassium
• Calcium

Topics

• Administration, Rectal
• Adolescent
• Adult
• Aged
• Calcium (blood)
• Chlorides (blood)
• Colon
• Drugs, Chinese Herbal (administration & dosage)
• Female
• Humans
• Hyperuricemia (blood, therapy)
• Male
• Middle Aged
• Peritoneal Dialysis (methods)
• Potassium (blood)
• Renal Dialysis (methods)
• Sodium (blood)
• Uric Acid (blood)
• Young Adult