[Salvage surgery for radiation failure in oral, oropharyngeal, and hypopharyngeal squamous cell carcinoma].

Abstract

Few reports have covered salvage surgery after radiotherapy, especially with chemotherapy for oral, oropharyngeal, and hypopharyngeal squamous cell carcinoma. The feasibility of salvage surgery is unclear. We analyzed postoperative complications and prognosis after salvage surgery for local recurrence after definitive radiotherapy. Subjects were 37 patients with oral, oropharyngeal, and hypopharyngeal squamous cell carcinoma treated from 1994 to 2003. Of these, 14 (37.8%) had postoperative complications. The complication rate was significantly high in the reconstructive operation group (p = 0.031) and the chemotherapy group (p = 0.049). The 5-year overall survival rate after salvage surgery was 70.7%. Although there was no significant improvement, the prognosis was good in early-stage groups with primary tumors. We found that salvage surgery after definitive radiotherapy was effective for recurrent oral, oropharyngeal, and hypopharyngeal squamous cell carcinoma. We stress the need to pay attention to postoperative complications in reconstructive operation and chemotherapy groups.

• Authors: Masahiro Suzuki, Akihiro Terada, Tetsuya Ogawa, Hidenori Suzuki, Yasuhisa Hasegawa
• Journal: Nihon Jibiinkoka Gakkai kaiho (Nihon Jibiinkoka Gakkai Kaiho) Vol. 110 Issue 6 Pg. 461-5 (Jun 2007) ISSN: 0030-6622 [Print] Japan
• PMID: 17633115 (Publication Type: English Abstract, Journal Article)

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (drug therapy, radiotherapy, surgery)
• Female
• Humans
• Hypopharyngeal Neoplasms (drug therapy, radiotherapy, surgery)
• Male
• Middle Aged
• Mouth Neoplasms (drug therapy, radiotherapy, surgery)
• Neoplasm Recurrence, Local
• Neoplasm Staging
• Oropharyngeal Neoplasms (drug therapy, radiotherapy, surgery)
• Salvage Therapy (mortality)
• Survival Rate
• Treatment Failure