Abstract | OBJECTIVE: METHODS: Rats were randomly divided into sham-operated group, untreated group, urokinase group (thrombolysis group), Naomaitong group, thrombolysis plus Naomaitong group. Cerebral ischemia was induced in rats by autonomous blood blot and inserted nylon thread. Rats were administrated with thrombolysis therapy through artery 3, 6 and 9 h after cerebral ischemia respectively. Twenty-four hours after the administration, mortality of the rats, and the brain and stomach hemorrhage ratios, as well as the pathological changes of the brain, lung and stomach were observed, and then cerebral infarct size (CIS) and lung water ratio (LWR) were measured. RESULTS: Compared with the sham-operated group, the rat mortality, and the brain and stomach hemorrhage ratios increased, the CIS enlarged, pathological changes of the brain, lung and stomach appeared obvious, and the LWR increased. Naomaitong plus thrombolysis treatment improved the changes above significantly. In the untreated rats with cerebral ischemia, injuries of the brain, lung and stomach were aggravated, the CIS enlarged and the LWR increased in the 9 h group as compared with those in the 3 h group. In the thrombolysis plus Naomaitong group, the pathological changes were improved, the CIS diminished and the LWR reduced. CONCLUSIONS:
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Authors | Jing-xia Liu, Jian-sheng Li, Dong Wang, Jing Su, Xiao-yan Guo, Jie Sun, Ning Li |
Journal | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
(Zhong Xi Yi Jie He Xue Bao)
Vol. 5
Issue 4
Pg. 451-6
(Jul 2007)
ISSN: 1672-1977 [Print] China |
PMID | 17631812
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- naomaitong
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Topics |
- Animals
- Brain Ischemia
(drug therapy)
- Combined Modality Therapy
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Female
- Lung
(blood supply)
- Male
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(prevention & control)
- Stomach
(blood supply)
- Thrombolytic Therapy
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