TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.

Abstract

Tumor-specific alteration of the TAL1 gene occurs in almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL). We now report the identification of TAL2, a distinct gene that was isolated on the basis of its sequence homology with TAL1. The TAL2 gene is located 33 kilobase pairs from the chromosome 9 breakpoint of t(7;9)(q34;q32), a recurring translocation specifically associated with T-ALL. As a consequence of t(7;9)(q34;q32), TAL2 is juxtaposed with sequences from the T-cell receptor beta-chain gene on chromosome 7. TAL2 sequences are actively transcribed in SUP-T3, a T-ALL cell line that harbors the t(7;9)(q34;q32). The TAL2 gene product includes a helix-loop-helix protein dimerization and DNA binding domain that is especially homologous to those encoded by the TAL1 and LYL1 protooncogenes. Hence, TAL2, TAL1, and LYL1 constitute a discrete subgroup of helix-loop-helix proteins, each of which can potentially contribute to the development of T-ALL.

• Authors: Y Xia, L Brown, C Y Yang, J T Tsan, M J Siciliano, R Espinosa 3rd, M M Le Beau, R J Baer
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 88 Issue 24 Pg. 11416-20 (Dec 15 1991) ISSN: 0027-8424 [Print] United States
• PMID: 1763056 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Basic Helix-Loop-Helix Transcription Factors
• DNA, Neoplasm
• DNA-Binding Proteins
• Neoplasm Proteins
• Oligodeoxyribonucleotides
• TAL2 protein, human
• Tal2 protein, mouse

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Basic Helix-Loop-Helix Transcription Factors
• Chromosomes, Human, Pair 7
• Chromosomes, Human, Pair 9
• DNA, Neoplasm (genetics, isolation & purification)
• DNA-Binding Proteins (genetics)
• Gene Expression Regulation, Neoplastic
• Genetic Linkage
• Humans
• Leukemia, T-Cell (genetics)
• Leukemia-Lymphoma, Adult T-Cell (genetics)
• Mice
• Molecular Sequence Data
• Neoplasm Proteins (genetics)
• Oligodeoxyribonucleotides
• Open Reading Frames
• Polymerase Chain Reaction (methods)
• Proto-Oncogenes
• Restriction Mapping
• Sequence Homology, Nucleic Acid
• Translocation, Genetic