| Abstract | BACKGROUND: The metabolic syndrome is a growing global public health problem. OBJECTIVE: To evaluate the prevalence rate and modal subcomponents of the metabolic syndrome in subjects treated at the West Los Angeles Veterans Administration Medical Center Bipolar Clinic. METHODS: In this cross-sectional design study, using the National Cholesterol Education Program definition, metabolic syndrome prevalence rates were calculated. RESULTS: 48/98 (49%) of subjects met criteria for metabolic syndrome. There was no difference in prevalence rate by gender or race. Almost 70% of the cohort met criteria for metabolic syndrome by the components of reduced HDL and increased waist circumference. Treatment with carbamazepine at study entry was associated with a lower prevalence rate of metabolic syndrome. LIMITATIONS AND CONCLUSIONS: This study is limited by its small size and non-structured assessment of Axis I diagnosis. Nonetheless, bipolar patients in this select cohort have high rates of metabolic syndrome; given this cardiovascular risk, close clinical monitoring for these parameters is recommended. While not controlling for genetics, environmental influences, and/or medical factors such as additional comorbidity and treatment duration, psychotropic drug use may confer differential risk for developing the metabolic syndrome. |
| Authors | Jeffrey Cardenas, Mark A Frye, Susan L Marusak, Eric M Levander, Jason W Chirichigno, Stryder Lewis, Shoshanna Nakelsky, Sun Hwang, Jim Mintz, Lori L Altshuler
(Affiliation: Department of Psychiatry, UCLA Mood Disorders Research Program, David Geffen School of Medicine at UCLA, Los Angeles, United States.)
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| Journal | Journal of affective disorders
(J Affect Disord)
Vol. 106
Issue 1-2
Pg. 91-7
(Feb 2008)
ISSN: 0165-0327 Netherlands |
| PMID | 17628693
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anticonvulsants
- Antimanic Agents
- Antipsychotic Agents
- Blood Glucose
- Cholesterol, HDL
- Triglycerides
|
| Topics |
- Adult
- Analysis of Variance
- Anticonvulsants
(adverse effects, therapeutic use)
- Antimanic Agents
(adverse effects, therapeutic use)
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Bipolar Disorder
(diagnosis, drug therapy, epidemiology)
- Blood Glucose
(metabolism)
- Cholesterol, HDL
(blood)
- Cohort Studies
- Comorbidity
- Cross-Sectional Studies
- Drug Therapy, Combination
- Female
- Humans
- Male
- Metabolic Syndrome X
(chemically induced, diagnosis, epidemiology)
- Middle Aged
- Risk Factors
- Triglycerides
(blood)
- Waist-Hip Ratio
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