Modal subcomponents of metabolic syndrome in patients with bipolar disorder.

• Abstract: BACKGROUND: The metabolic syndrome is a growing global public health problem. OBJECTIVE: To evaluate the prevalence rate and modal subcomponents of the metabolic syndrome in subjects treated at the West Los Angeles Veterans Administration Medical Center Bipolar Clinic. METHODS: In this cross-sectional design study, using the National Cholesterol Education Program definition, metabolic syndrome prevalence rates were calculated. RESULTS: 48/98 (49%) of subjects met criteria for metabolic syndrome. There was no difference in prevalence rate by gender or race. Almost 70% of the cohort met criteria for metabolic syndrome by the components of reduced HDL and increased waist circumference. Treatment with carbamazepine at study entry was associated with a lower prevalence rate of metabolic syndrome. LIMITATIONS AND CONCLUSIONS: This study is limited by its small size and non-structured assessment of Axis I diagnosis. Nonetheless, bipolar patients in this select cohort have high rates of metabolic syndrome; given this cardiovascular risk, close clinical monitoring for these parameters is recommended. While not controlling for genetics, environmental influences, and/or medical factors such as additional comorbidity and treatment duration, psychotropic drug use may confer differential risk for developing the metabolic syndrome.
• Authors: Jeffrey Cardenas, Mark A Frye, Susan L Marusak, Eric M Levander, Jason W Chirichigno, Stryder Lewis, Shoshanna Nakelsky, Sun Hwang, Jim Mintz, Lori L Altshuler (Affiliation: Department of Psychiatry, UCLA Mood Disorders Research Program, David Geffen School of Medicine at UCLA, Los Angeles, United States.)
• Journal: Journal of affective disorders (J Affect Disord) Vol. 106 Issue 1-2 Pg. 91-7 (Feb 2008) ISSN: 0165-0327 [Print] Netherlands
• PMID: 17628693 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticonvulsants
• Antimanic Agents
• Antipsychotic Agents
• Blood Glucose
• Cholesterol, HDL
• Triglycerides

Topics

• Adult
• Analysis of Variance
• Anticonvulsants (adverse effects, therapeutic use)
• Antimanic Agents (adverse effects, therapeutic use)
• Antipsychotic Agents (adverse effects, therapeutic use)
• Bipolar Disorder (diagnosis, drug therapy, epidemiology)
• Blood Glucose (metabolism)
• Cholesterol, HDL (blood)
• Cohort Studies
• Comorbidity
• Cross-Sectional Studies
• Drug Therapy, Combination
• Female
• Humans
• Male
• Metabolic Syndrome X (chemically induced, diagnosis, epidemiology)
• Middle Aged
• Risk Factors
• Triglycerides (blood)
• Waist-Hip Ratio