Abstract |
A novel series of 1-anilino-5H-pyridazino[4,5-b] indoles was designed and synthesized in order to find novel potent anti- tumor compounds. Their structures were confirmed by MS, (1)H-NMR, and elemental analysis. All compounds were screened for their cytotoxic activity against two human cancer cell lines (Bel-7420, HT-1080). The compounds 8, 9, and 17 showed 50% growth inhibitory activity in low micromolar concentration (IC(50 )= 7.7 approximately 12.8 microM). Among them, compound 17 displayed the most potent anti- tumor activity with IC(50) values of 8.2 microM and 7.9 microM against Bel-7402 and HT-1080, respectively.
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Authors | Rong Dong Li, Xin Zhai, Yan Fang Zhao, Shuang Yu, Ping Gong |
Journal | Archiv der Pharmazie
(Arch Pharm (Weinheim))
Vol. 340
Issue 8
Pg. 424-8
(Aug 2007)
ISSN: 0365-6233 [Print] Germany |
PMID | 17628035
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Indoles
- Pyridazines
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Topics |
- Antineoplastic Agents
(chemical synthesis, pharmacology)
- Cell Line, Tumor
- Humans
- Indoles
(chemical synthesis, pharmacology)
- Pyridazines
(chemical synthesis)
- Structure-Activity Relationship
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