Development and medical application of unsaturated carbaglycosylamine glycosidase inhibitors.

Abstract

This article reviews synthesis and structures of carbaglycosylamines, a group of carbocyclic sugar analogues. Some unsaturated derivatives are known to be potent glycosidase inhibitors. Among them, N-octyl-4-epi-beta-valienamine as a lysosomal beta-galactosidase inhibitor is currently undergoing a new molecular therapeutic trial (chemical chaperone therapy) for control of the human beta-galactosidase deficiency disorder, G(M1)-gangliosidosis.

• Authors: Seiichiro Ogawa, Miki Kanto, Yoshiyuki Suzuki
• Journal: Mini reviews in medicinal chemistry (Mini Rev Med Chem) Vol. 7 Issue 7 Pg. 679-91 (Jul 2007) ISSN: 1389-5575 [Print] Netherlands
• PMID: 17627580 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cyclohexenes
• Enzyme Inhibitors
• Hexosamines
• Molecular Chaperones
• N-octyl-beta-valienamine
• valienamine
• Glycoside Hydrolases

Topics

• Animals
• Cyclohexenes (chemistry, pharmacology, therapeutic use)
• Drug Design
• Enzyme Inhibitors (chemistry, pharmacology, therapeutic use)
• Gangliosidosis, GM1 (drug therapy)
• Glycoside Hydrolases (antagonists & inhibitors)
• Hexosamines (chemistry, pharmacology, therapeutic use)
• Humans
• Mice
• Molecular Chaperones (chemistry, pharmacology, therapeutic use)
• Structure-Activity Relationship